Harlequinmania

Posting on behalf of a friend here . Currently want sell away a clown trigger 3.5/4inches for 50$ ( price negotiable : eat everything and very healthy) Collection ; Near upper serrangoon ( 33 sommerville road ) Please contact nick name ; flo_reeftank or florent @ 9221-5990

Click through to see the images. From the ARC Centre of Excellence for Coral Reef Studies Researchers at the ARC Centre of Excellence for Coral Reef Studies (CoECRS) have found three genes in Acropora (staghorn) corals which show a very fast, strong immune response to the presence of bacteria – and the same genes also occur in mammals, including people. “It’s early days, but it certainly looks as if key aspects of our ability to resist bacteria are extremely ancient and may have been pioneered by the ancestor of corals – and then passed down to humans in our evolutionary lineage,” explains team leader Professor David Miller of CoECRS and James Cook University. “Corals are constantly attacked by bacteria in their natural environment, and so have perfected very efficient defences against them,” he says. “These defences apparently work well enough to be preserved in mammals like us, and possibly in plants too. Certain animals in between us and coral, like roundworms and flies, seem to have lost these genes, but our line appears to have retained them.” The genes belong to a family known as the GiMAPs and have been associated with anti-bacterial immunity in mammals, including humans. The team made its discovery by challenging living colonies of Acropora with certain chemicals commonly found in the coats of bacteria, and studying which genes reacted across virtually its entire genome of 20,000-plus genes. “We were quite surprised at how rapidly and strongly these three genes in particular reacted to the presence of bacterial proteins,” Prof. Miller says. “It was spectacular.” The main goal of the research is to better understand the mechanisms by which corals resist attack by bacteria and viruses – an urgent task in view of a massive upsurge in coral diseases around the world, which researchers attribute to the impact of human activity on the oceans and on coral reefs themselves. “By better understanding the basis of coral immunity we may first be able to understand what is causing this pandemic of coral diseases and how human activity is connected to it. “And second, this may lead us to better ways of managing our reefs that reduce the impact of disease, and give corals a better chance of survival during a period of major climatic and environmental change,” he says. Prof. Miller has also been involved with an international team in a second, equally important discovery – helping for the first time to clarify the molecular process by which corals form their calcium-rich skeletons. “With the world’s oceans becoming more acidic due to man-made carbon dioxide emissions, the whole basis by which corals and other marine organisms form their skeletons and shells – known as calcification – is under threat. “Many marine scientists fear that if the oceans become more acidic as we redouble fossil fuel use, many of these lifeforms will not be able to cope – and our coral reefs could literally dissolve before our very eyes,” he explains. “Understanding how coral forms its skeleton at the molecular level is part of the basic science required to properly understand what is going on in the world’s coral reefs, and to predict the outcome with some certainty. At the moment, while we fear acidification will be damaging for corals, we don’t know how bad – whether it will affect all corals equally, whether it will inflict extensive damage, or will wipe them out completely.” Prof Miller says that the most important implication of ongoing work which builds on the published study is that, while corals can to some extent cope with ocean acidification on its own, the combination of increasing temperature and acidity are much more damaging. “This is significant, because climate change will result in just those conditions that are most harmful to skeleton formation and maintenance,” he says. “Corals have been around for a long time, and over hundreds of millions of years the coral lineage has survived previous periods of ocean acidification. However, modern coral reefs are fragile things, and reefs as we know them may not exist in the later part of this century if we do not deal immediately with global CO2 emissions”. Details of the research appear in the following scientific papers: Acute transcriptional response of the coral Acropora millepora to immune challenge: expression of GiMAP/IAN genes links the innate immune responses of corals with those of mammals and plants, by Yvonne Weiss, Sylvain Forêt, David C Hayward, Tracy Ainsworth, Rob King, Eldon E Ball and David J Miller, in BMC Genomics, June 2013. Citation: Weiss et al. BMC Genomics (2013) 14:400. The skeletal proteome of the coral Acropora millepora: the evolution of calcification by cooption and domain shuffling, by Paula Ramos-Silva, Jaap Kaandorp, Lotte Huisman, Benjamin Marie, Isabelle Zanella-Cléon, Nathalie Guichard, David J. Miller and Frédéric Marin, in Molecular Biology and Evolution, June 2013. Read more about Coral immunology at our partner website, Coralscience.org. View the full article

Click through to see the images. The time is here once again for the Marine Breeder's Workshop, held yearly in Bloomfield Hills, Michigan at the Cranbrook Institute of Science. This is the fourth annual event and this year's schedule of events is shaping up to be another great one with a list of great speakers, raffle, and social time so attendees can get to know others in the hobby that share their passion. The Workshop will begin with presentations relating to the captive breeding of marine organisms by our first speakers, followed by a break for lunch. After lunch we will finish with the final two speakers. Attendees will have plenty of "one on one" time to ask questions and discuss their own, personal, breeding efforts both during and after the event. The Workshop will be held at the Cranbrook Institute of Science on Saturday, July 13, 2013. Check in Starts at 8:30 am and program will start promptly at 9:00 am. Speaking this year will be: Matthew Carberry (founder of Sustainable Aquatics) Chad Clayton: "Culturing rotifers and copepods for use in marine ornamental larviculture", Reed Mariculture Martin Moe: "Structure and operation of a unique culture system for rearing the larvae of Diadema antillarum, the long-spined sea urchin of Atlantic coral reefs" David Watson (large animal veterinarian): experiences breeding Cardinalfish, beyond Banggais, and give tips on constructing a larval rearing system for the small fishroom. Tickets for this year's event cost $45 for adults and $20 for students 16 and under. Tentative Schedule of events: Friday, July 12: Informal reception at the Marriott Centerpoint - 8PM in the lobby bar Saturday, July 13: Workshop Registration - 8:30AM at the Cranbrook Institute of Science Speaker Schedule - TBA Speaker I: David Watson 9:30 - 10:30 Speaker II: Chad Clayton 11:00 - 12:00 Lunch: 12:00 - 1:00 MBI Awards: 1:00 - 1:30 Speaker III: Matthew Carberry 1:30 - 2:30 Special Guest Speaker: 2:45 - 3:00 Speaker IV: Martin Moe 3:15 - 4:15 Sunday, July 14: Post-Workshop BBQ at Fishtal Propagations - 1PM 4680 Sherbourne Ave Waterford, MI 48327 I have personally attended the last two Workshops and highly recommend it to anyone that is interested in breeding marine ornamentals. View the full article

Click through to see the images. Yes; The video is a bit grainy (even in 1080 HD) and overly saturated, but this reef tank is undeniably beautiful and brimming with all sorts of life. Soft corals and fishes add dynamic movement to the display while the other invertebrates add structure and color. And then there's the two impressive large moray eels that you don't often see in coral reef aquariums. It's really cool to see them naturally glide their way through the reef. Hopefully the eels (especially the large zebra moray) don't make fast meals of the small fish in the tank. " height="383" style="width: 680px;" type="application/x-shockwave-flash" width="680"> "> View the full article

Click through to see the images. The State's Department of Land and Natural Resources has decided to impose new limitations on what species collectors may take from the Big Island's Kona coast. In response to the decision, William Aila, DLNR's head and one of the two dissenting board members, stated: “I was disappointed with the outcome because I believe we need more scientific data before taking a step that will affect fishers’ lives." Advanced Aquarist is awaiting the list of permitted species (and by extension, the list of newly prohibited fish) in addition to other details about Hawaii's DLNR latest decision. We will share more information as they become available. The Board also ruled to ban SCUBA spearfishing at Kona in addition to redrawing the boundaries of a fishery management area off Puako. View the full article

Click through to see the images. The State's Department of Land and Natural Resources has decided to impose new limitations on what species collectors may take from the Big Island's Kona coast. In response to the decision, William Aila, DLNR's head and one of the two dissenting board members, stated: “I was disappointed with the outcome because I believe we need more scientific data before taking a step that will affect fishers’ lives." Advanced Aquarist is awaiting the list of permitted species (and by extension, the list of newly prohibited fish) in addition to other details about Hawaii's DLNR latest decision. We will share more information as they become available. The Board also ruled to ban SCUBA spearfishing at Kona in addition to redrawing the boundaries of a fishery management area off Puako. View the full article

Click through to see the images. Alex Spiride, age 13 is one of 15 Google Science Fair finalists. He entered his squid-inspired propulsion system in the 13-14 year old category for this year's science fair under the title "Squid-Jet: Bio-Inspired Propulsion System for Underwater Vehicles." Spiride states that "Squid and some other sea creatures use a very efficient mode of locomotion, know as jet propulsion. Squid will draw water into a bladder through a hole called the mantle, and then they force it out, by contracting the bladder, to shoot forwards in speeds of up to 40 km/hour. Implementing this technique in underwater vehicles can vastly improve the efficiency with which they locomote. My proposal is Squid-Jet, a bio-inspired underwater vehicle that uses jet propulsion to its advantage. Squid-Jet easily outperforms current man-made propulsion systems and can reach speeds in excess of 30 cm/second." His project uses a pressurized PVC enclosure and uses an internal bladder to create a hydrojet, which moves his vehicle forward. When the PVC enclosure is pressurized with air, it forces water contained in the bladder out the back through a nozzle, propelling the enclosure forward. Water is then sucked back into the bladder when the pressure is reduced. Cycling this pressure / release back and forth propels his PVC enclosure forward (see video below). Spiride's project is quite impressive and he lists a number of different applications for the Squid-Jet ranging from underwater exploration, oil spill cleanup, marine biology studies, defense systems, natural gas, oil, or water pipelines. (via Hackaday) View the full article

Click through to see the images. How many of you will attend this year? View the full article

Lck still have shoal tang, purple tang, baby size flame back, blue line angel, emperor, Japanese angel, gem tang, conspicuous angel , cleaner shrimp and peppermint shrimp.

Click through to see the images. About the artist in his own words: I was born and raised in Africa. The bush is in my blood, and for as long as I can remember that is where I have found the most happiness. Educated in Zimbabwe, at Christian Brothers College, I pursued my artistic career at Rhodes University in South Africa. There I earned a Bachelor of Fine Arts (Honours) with Distinction, also winning the Purvis Prize for highest Honours practical results. I have sold artworks to wildlife enthusiasts across the globe, and strive to hone my style and my skills through each new medium. My grounding in the bush, and my affinity for wildlife help me capture the 'essence' of the animal, by understanding the behaviour and habitat I strive to create an emotion around the artwork, not just a photographic reproduction. I will always be an African, and I will always keep this wild continent close to my heart, and close to my work. Make sure to checkout Luca's website for more of his jaw-dropping nature artwork and photography. We guarantee you will not be disappointed (except perhaps that there isn't enough art and photos to browse). More fish art, Mr. Grant! Pretty please! [via reddit/r/aquariums] View the full article

Putting this set of Ecoxotic 50W LED for sales again since i already converted to a FOWLR tank month ago, and the light has been sitting around not running. 2 unit of Ecoxotic 50W cannon LED ( White ) @ $ 400.00 / pcs 2 Unit of Ecoxotic 50W cannon LED ( Blue ) @ $ 400.00 / pcs Take all 4 unit @ $ 1500.00 Lighting set is about 15 month, but actually running time is shorter than that since i stop running it after switching to fowlr. Will also include the wall railing and cable F.O.C for buyer whom get all 4 pcs of light. more information about this light can be found here ; http://www.ecoxotic.com/aquarium-led-lights/cannon-pendants/cannon-led-pendants.html Viewing collection at CCK.

Click through to see the images. Read Part I of Richard's article in the May issue. Last time I took you on a tour of The Deep's tanks, its exhibits and its mind bogglingly huge systems. I marveled at the eleven metre high skimmer and the 30,000litre water changes that are regular components in the maintenance of the massive Endless Oceans exhibit. In this piece I want to showcase some of The Deep's conservation work, its educational work and its leading role in captive breeding. Firstly let's look at jellyfish. The Deep raises an awful lot of jellyfish. Jellies at The Deep On my tour, one of the first things that took my eye was the enormously complicated looking jellyfish raising area, which has been created and designed by The Deep's team of aquarists. It looked complicated, but it clearly works, which is fortunate; with so many jellies on display, The Deep needs to breed its own stock and its success means The Deep now supplies other aquaria. Free swimming larvae are grown on in goldfish bowls, prior to transfer to Kreisel tanks. Moon Jellyfish (Aurelia sp.) Lion’s Mane Jellyfish – at the time the largest jellyfish in captivity in the world. Image: The Deep. The Deep has several tanks which display jellyfish, mainly moon jellyfish. Several other species, such as Cassiopeia, the upside down jellyfish, are on display and in the past, The Deep has played host to a lion's mane jellyfish which was caught by accident by a local fisherman. Breeding the jellies is a full time job and takes some explanation. It all starts with a 'culture' colony of the non motile jellyfish polyps. In this early stage of the jellies' life-cycle they resemble small white anemones, a little like small Aiptasia. These polyps are attached to rock, where they strobulate; releasing small free-swimming medusa which grow to become the jellies we are familiar with. To ensure the jellyfish are not damaged they need to be housed in a specially designed kreisel type tanks, where currents keep them in circulation in the water column. It is essential that the jellies are not troubled by bubbles, which can become lodged inside them and cause a great deal of damage Several Kreisel tanks, designed by the Deep team, stand ready to take jellyfish. Promoting Responsibility in the Aquarium Industry One message that I took away with me from my visit was the team's belief that we aquarists can do more to ensure the hobby is as sustainable and ethical as possible. Katy Duke, the Deep's Curator showed me their Amazonian Flooded Forests display, which contained several fish that had been donated to the Deep as they'd outgrown their owner's tanks. "We have to say 'no' most of the time" she said "We simply cannot offer a home to every fish that we are offered. There is always a pattern of species that we see being offered due to the size these fish get. It is a myth that fish only grow to the size of their tank! They will grow to the size nature intended or die early as a result of inappropriate conditions. There are a number of species that are really not appropriate for the average home aquarium, our displays also have a maximum capacity and therefore we cannot compromise the welfare of our own animals by endlessly taking on unwanted pets." When you see shops selling small specimens of red-tailed catfish, pangasius catfish and pacu; you know the fish is destined to be disposed of before it can reach anywhere near its adult size. There seems to be a 'disposable' mentality with fish and a lack of careful consideration when choosing the appropriate species to sell or buy. The British and Irish Association for Zoos and Aquariums (BIAZA) Aquarium Working Group and relaunching the Big Fish campaign to raise awareness of the issue and to get importers, retailers and the public on side to support the concept that a 'fish is for life' and therefore if you choose a fish that will grow to two metres you really need to consider where you are going to house it at that size. The Deep practices what they preach as well and ensure all their stock is caught within the strict Marine Aquarium Council's guidelines. Captive Breeding The Deep has had some great successes with captive breeding. Back in 2005 the Deep was the first facility to breed blue spotted ribbon tail rays, a species from the Indo Pacific. The Flooded Forests tank from above, some of the large fish in here were once home aquarium specimens. Blue spotted ribbon tail rays, known as 'Raif' and 'Charity'. Image: Lorne Campbell, GUZELIAN The Deep is also very proud of its pair of Green Sawfish and hopes to be the first site to breed these very rare fish in captivity. Green Sawfish numbers in the wild have crashed due to overfishing and habitat loss, so every snippet of information about their breeding will help inform conservation efforts in the wild. Education The Deep has a dedicated education team that work with schools from across the country and has 30,000 pupil visits per year. Deep1 - the Deep's dedicated education area. Education sessions include options from maths, science and geography curriculums. Students can even learn about maths by using The Deep as a real world example, by putting themselves in the role of the aquarists and having to decide which animals to buy on a fixed budget. Personally I like the sound of the Underwater Art option. It all sounds far more interesting than the school trips of the early 1970s that I endured. Image: Karl Andre. Conservation in the Wild As I noted in the first part of this article, the Deep is a not for profit organisation, its profits are ploughed back into the care of its exhibits and into education and conservation programmes. One of these is the funding of a Ranger as part of a World Land Trust project to explore the biodiversity of the Atlantic rainforest of Brazil. It's going away from UltraMarine's remit here, but The Deep has some cracking freshwater systems and terrariums, which showcase terrestrial habitats and make references to conservation and biodiversity issues in freshwater and terrestrial environments. A lovely planted tank with mosquito raspbora (Boraras briggitae). In the seas the team have undertaken some fascinating work with the Equipe Cousteau organisation, set up by Jacques Cousteau's descendants. In 2009 The Deep and Equipe Cousteau worked together on a Manta ray tagging project off the Sudanese coast to further understand the rays' patterns of migration and how their long distance travels affect their conservation status. Eunicella verrucosa, a cold water, slow-growing gorgonian, easily damaged by trawlers and divers alike. Closer to home The Deep has been working with Natural England, the Zoological Society of London and Yorkshire Water to learn more about the Pink Sea Fan Eunicella verrucosa which is a British coral found off the South West coast. In the last few weeks one of The Deep team, Assistant Curator Andrew Mcleod, has joined a team of scientists from SECORE, which is an international organisation investigating the sexual reproduction of coral. It aims to help restore endangered coral populations around the world. They will be working off the Caribbean coast of Belize. The team are diving each night to witness the massive spawning events of four different species of coral - including elkhorn (Acropora palmata) and staghorn (Acropora cerviconis). Spawning only takes place over a few nights after a full moon each August, so the team have to plan accordingly. The gametes drift to the surface where fertilisation occurs. The resulting coral larvae (planulae) which swim for two or three days before sinking to the bottom grow into larger coral colonies over time. During the spawning, scientists will collect the delicate 'gametes' in specially designed nets and fertilise them in a laboratory on land. Once fertilised, they will be carefully transported to participating aquariums. Andrew will be returning to Hull with some larvae which will settle out and grow in a specially prepared coral table in The Deep's quarantine facility. UK Native Marines The Deep has a fascinating collection of native species and has a dedicated Cool Seas exhibit area. Not only can visitors meet not so native nautilus but they can learn more about the amazing sea life off the UK coast: with some stunning anemones on display along with a range of fish species that we are normally only aware of when passing the fish counter at the supermarket. Possibly the ugliest fish on display – the Wolf Eel. Image: Linda Pitkin Whilst these exhibits aren't the most impressive (in comparison to Endless Oceans) they are superb and in my opinion do a great job of showing visitors just what can be found within a few miles of where they stand. I can honestly say that I thoroughly enjoyed my visit to the Deep and I recommend it to anyone with an interest in the underwater world. My thanks to Linda Martin and Katy Duke. For further information, opening times and prices, how to book school visits, weddings, or even enjoy a meal in front of the main tank, please see The Deep's website: http://www.thedeep.co.uk/. iPhone and Android users can also download an app called iDeep, packed with information about the exhibits. View the full article

Click through to see the images. GlennF's display tank measures 250x80x58cm (~100x32x23"), which equates to roughly 320 US gallons in volume. From his photos, we know his aquarium is lit by T5s, and the system appears to have multiple refugiums attached to the main display tank. GlennF also employs a lot of dosing pumps and reactors. Details about the DSR Method are also unfortunately scarce. From what we have gathered, the method centers around the core principle of very limited water change and targeted home-made additives to correct levels of "salinity, kH, calcium, manganese, iodine, potassium, boron, nitrate, phosphate, and iron," although as we previously alluded to, details about the exact procedures are not described. GlennF has written a very extensive calculator spreadsheet (currently available in Dutch but he is working on a English version) to help maintain target parameters. GlennF also supplies a "carbon source and amino acids." Essentially, the DSR Method is a ULNS (Ultra Low Nutrient System) variant which aims to maintain water parameters with careful monitoring and supplementation in place of water changes. While we are not sure how many reefkeepers would choose to constantly test multiple parameters and administer additives versus water changes, GlennF's results are impressive. His aquarium (and DSR experiment) has been going strong for 8 years. GlennF is active on multiple Dutch online communities and also has an English thread at Reef Central, where you can find a lot more photos of his aquarium. We just wish he would update us about his equipment and details about his methodology. Here is a recently uploaded video of his "DSR" coral reef aquarium: " height="383" type="application/x-shockwave-flash" width="680"> "> "> View the full article

Just from the look of the skimate we can tell it is a effective skimmer lo.. What skimmer is this ?

Click through to see the images. Researchers at Northwestern University have revealed some of the mechanical properties that allow fish to perform their complex movements. Their findings, published on June 13 in the journalPLOS Computational Biology, could provide insights in evolutionary biology and lead to an understanding of the neural control of movement and development of bio-inspired underwater vehicles. “If we could play God and create an undulatory swimmer, how stiff should its body be? At what wave frequency should its body undulate so it moves at its top speed? How does its brain control those movements?” said Neelesh Patankar, professor of mechanical engineering at Northwestern’s McCormick School of Engineering and Applied Science. “Millennia ago, undulatory swimmers like eels that had the right mechanical properties are the ones that would have survived.” The researchers used computational methods to test assumptions about the preferred evolutionary characteristics. For example, species with low muscle activation frequency and high body stiffness are the most successful; the researchers found the optimal values for each property. “The stiffness that we predict for good swimming characteristics is, in fact, the same as the experimentally determined stiffness of undulatory swimmers with a backbone,” said Amneet Bhalla, graduate student in mechanical engineering at McCormick and one of the paper’s authors. “Thus, our results suggest that precursors of a backbone would have given rise to animals with the appropriate body stiffness,” added Patankar. “We hypothesize that this would have been mechanically beneficial to the evolutionary emergence of swimming vertebrates.” In addition, species must be resilient to small changes in physical characteristics from one generation to the next. The researchers confirmed that the ability to swim, while dependent upon mechanical parameters, is not sensitive to minor generational changes; as long as the body stiffness is above a certain value, the ability to swim quickly is insensitive to the value of the stiffness, the researchers found. Finally, making a connection to the neural control of movement, the researchers analyzed the curvature of its undulations to determine if it was the result of a single bending torque, or if precise bending torques were necessary at every point along its body. They learned that a simple movement pattern gives rise to the complicated-looking deformation. “This suggests that the animal does not need precise control of its movements,” Patankar said. To make these determinations, the researchers applied a common physics concept known as “spring mass damper” — a model, applied to everything from car suspension to Slinkies, that determines movement in systems that are losing energy — to the body of the fish. This novel approach for the first time unified the concepts of active and passive swimming — swimming in which forcing comes from within the fish (active) or from the surrounding water (passive) — by calculating the conditions necessary for the fish to swim both actively and passively. The paper, “A Forced Damped Oscillation Framework for Undulatory Swimming Provides New Insights into How Propulsion Arises in Active and Passive Swimming,” was authored by Patankar, Bhalla, and Boyce E. Griffith, assistant professor of medicine and mathematics at New York University. The work was supported by the National Science Foundation (NSF). (Press Release: http://www.mccormick.northwestern.edu/news/articles/2013/06/how-fish-swim-mccormick-researchers-examine-mechanical-bases-for-the-emergence-of-undulatory-swimmers.html) View the full article

Click through to see the images. Irvine, CA & Seattle, WA — Scientists at UC Irvine reported this week that a synthetic compound ShK-186, originally derived from a sea anemone toxin, has been found to enhance metabolic activity and shows potential as a treatment for obesity and insulin resistance. The findings published the week of May 27 in the Proceedings of the National Academy of Sciences reveal that ShK-186 selectively blocks the activity of a protein that promotes inflammation through the Kv1.3 potassium channel. The study presents the first evidence that the drug candidate – which in March showed positive results in a Phase 1 safety clinical trial – may also work in an anti-obesity capacity. UC Irvine licensed ShK-186 to Kineta Inc., a Seattle based biotechnology company in 2009; it is the company's lead drug candidate. Kineta is developing this compound to treat autoimmune diseases, such as multiple sclerosis, psoriatic arthritis and lupus. It has also licensed the use of ShK-186 for the treatment of metabolic syndrome and obesity. Potassium channels regulate cell membrane potential and control a variety of cellular processes. Earlier studies using mice that lack Kv1.3, a potassium channel gene, suggested that Kv1.3 regulated body weight and the basal metabolic rate. In the present study, Dr. George Chandy and his colleagues evaluated ShK-186 because it has high selectivity for the Kv1.3 target, a favorable pharmacokinetic profile, and meets the qualities of an industry-standard drug. In tests on obese mice that ate a high-fat, high-sugar diet, ShK-186 therapy reduced weight gain, white fat deposits, fatty liver, blood cholesterol and blood sugar by activating calorie-burning brown fat, suppressing inflammation of white fat and augmenting liver function. The compound had no effect on mice that ate a standard chow diet, suggesting that the obesity-causing diet triggers the expression of the Kv1.3 target. "This is a new twist in a sustained journey of discovery made over the 30 years that charts the course for expeditious translation to humans who suffer from potentially lethal consequences of metabolic syndrome and autoimmune diseases," said Chandy, professor of physiology & biophysics at UC Irvine and a Kineta scientific advisor. "We evaluated ShK-186 in an obesity model because it has high selectivity for the Kv1.3 target, a favorable pharmacokinetic profile, and meets the qualities of an industry-standard drug." "These data are quite exciting and strongly support the notion that inhibition of the Kv1.3 channel provides a highly effective method for managing obesity and its associated metabolic abnormalities. The results obtained with ShK-186 are consistent with what one would expect to see with a potent inhibitor of this channel. While additional studies are needed, the potential clinical relevance of this work is enormous, since a significant number of people are afflicted with obesity and its associated complications, and no Kv1.3 inhibitor, as a drug candidate for obesity, has reached the clinic until now," said Dr. Gary V. Desir, professor of medicine at Yale University, and an expert on the Kv1.3 channel's role in renal potassium secretion and glucose metabolism. Dr. Desir was not involved with the study. "Knowing that ShK-186's unique mechanism of action may have broad utilization across multiple therapeutic disciplines, such as autoimmune diseases and now obesity, further adds to the potential of this compound. This study also shows how medical progress can be made through academic and private sector partnerships," added Charles Magness, Ph.D., President and CEO of Kineta. According to the World Health Organization (March 2013), obesity worldwide has nearly doubled since 1980. In 2008, more than 200 million men and nearly 300 million women, or 11 percent, were obese. Diabetes is expected to affect roughly 300 million humans by 2030 with an economic cost of $260 billion annually. Sanjeev Kumar Upadhyay, Kristin Eckel-Mahan, M. Reza Mirbolooki, Indra Tjong, Galina Schmunk, Briac Halbout, Brian Pedersen, Emiliana Borrelli, Ping H. Wang, Jogeshwar Mukherjee, and Paolo Sassone-Corsi with UC Irvine; Amanda Koehne and Stephen M. Griffey with UC Davis; and Shawn Iadonato with Kineta contributed to the study, which received support from the National Institutes of Health, a UC Irvine bridge grant, and the Ko Family Foundation. About Kv1.3 Research at UCI Dr. Chandy and his UC Irvine colleague Michael Cahalan discovered Kv1.3 in 1984, and since then they have characterized the role of this channel in immune cells. In the 1990s, Chandy and colleagues found that ShK, a peptide from sun anemone venom, blocks Kv1.3 with high potency. They created a synthetic version, ShK-186, and demonstrated its usefulness in treating autoimmune diseases in animal models. ShK-186 is now under pharmaceutical development at Kineta. About ShK-186 Kineta's lead clinical stage program, ShK-186, is a selective and potent blocker of the voltage-gated Kv1.3 potassium channel. Originally developed from the toxic tentacles of the sun anemone, Stichodactyla helianthus, ShK-186 is a synthetic peptide with a novel mechanism of action that targets autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, and lupus, without broadly suppressing the immune system. ShK-186 was the first Kv1.3-specific inhibitor advanced into the clinic and was well tolerated in a Phase I clinical study that was completed in March 2013. About UCI Founded in 1965, UC Irvine is a top-ranked university dedicated to research, scholarship and community service. Led by Chancellor Michael Drake since 2005, UC Irvine is among the most dynamic campuses in the University of California system, with more than 28,000 undergraduate and graduate students, 1,100 faculty and 9,400 staff. Orange County's second-largest employer, UC Irvine contributes an annual economic impact of $4.3 billion. For more UC Irvine news, visit news.uci.edu. About Kineta, Inc. Kineta is a Seattle-based privately held biotechnology company specializing in clinical advancement of novel drug candidates derived from leading edge scientific research. Our world class scientists are pioneers in developing life-changing classes of new drugs designed to be more effective and safer than current medicines. Kineta seeks to improve the lives of millions of people suffering from autoimmune and viral diseases and from severe pain. Our progressive business model focuses on targeting unmet medical needs and rapid achievement of important clinical milestones. For more information on Kineta, Inc. visit our website, http://www.Kinetabio.com View the full article

It is really a maze inside the market and you can easily get loss . As what thomas said try looking for the JJ mall building which is much easier to find. There is also one big freshwater aquarium shop located in the basement of JJ mall worth checking out.

Yes. A effective protein skimmer will break down organic waste / nutrient before it break down into Nitrate.

Click through to see the images. In 2004, MBA became the first aquarium to keep a great white shark for longer than 16 days. A female that was accidentally caught by commercial fishing nets was maintained in MBA's 1.2 million gallon Open Sea exhibit for 198 days (growing 14 inches during her time in captivity) before being released back into the wild. The shark was released after attacking other sharks in the exhibit. Since then, MBA has kept five more great white sharks with mixed success. Some of these were caught accidentally while others were obtained through purposeful collection. While none died in captivity, some of these finicky sharks had to be released early because they refused to eat in captivity. MBA officials have decided not to attempt more great white sharks in the wake of increased public pressure to list this species for endangered species protection status. Also noteworthy is that while the first great white shark at MBA drew in large increases in aquarium attendance, subsequent great whites did not. View the full article

Click through to see the images. Mac users can download the beta software at: http://www.Pacific-Sun.eu/download/mac_beta15/PacificSun_Beta_1.5.app.zip. Here are some screen shots of Pacific Sun Mac OS software beta version 1.5. This version is already currently available for PCs. View the full article

Click through to see the images. Mac users can download the beta software at: http://www.Pacific-Sun.eu/download/mac_beta15/PacificSun_Beta_1.5.app.zip. Here are some screen shots of Pacific Sun Mac OS software beta version 1.5. This version is already currently available for PCs. View the full article

Hopefully we can get to see some of the captive breed clarion on out shore one day. The owner is a taiwanese whom live in bali. Sent from my GT-I9300 using Tapatalk 2

Aquamarin still have some left over sps, and hard corals. Fishes ; grey belly regal, juv emperor, small blue tang, amd bi color angel ect. . Also they are having a Moving out sales 20-30% till 25th this month. Sent from my GT-I9300 using Tapatalk 2

Click through to see the images. Using the programming language Processing, he succeeded. According to Kemper, the initial version was made to work with the Microsoft Kinect and is shown in the video below: In addition, he created a webpage where people online can also play with the effect as well. Go to http://distantshape.com/experiments/squid/ to check it out. Move your mouse cursor over the "chromophores" and click around to see the chromophores expand and pulsate. For those that missed it, here is the video where squid chromophores pulse to Cypress Hill's Insane in the Membrane: (via Hackaday) View the full article

Click through to see the images. Advanced Reef Aquarium is the sister channel to the more established Tidal Gardens. While Tidal Gardens focuses on coral aquaculture, Advanced Reef Aquarium specializes in the equipment side of the hobby. Their video production is top notch. " height="383" type="application/x-shockwave-flash" width="680"> "> "> View the full article